How does Lin28 let-7 control development and disease?
Abstract
One of the most ancient and highly conserved microRNAs (miRNAs), the let-7 family, has gained notoriety owing to its regulation of stem cell differentiation and essential role in normal development, as well as its tumor suppressor function. Mechanisms controlling let-7 expression have recently been uncovered, specifically the role of the RNA-binding protein Lin28 - a key developmental regulator - in blocking let-7 biogenesis. This review focuses...
Paper Details
Title
How does Lin28 let-7 control development and disease?
Published Date
Sep 1, 2012
Journal
Volume
22
Issue
9
Pages
474 - 482
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