Design, modification and 3D QSAR studies of novel naphthalin-containing pyrazoline derivatives with/without thiourea skeleton as anticancer agents
Abstract
Two series of novel naphthalin-containing pyrazoline derivatives C1-C14 and D1-D14 have been synthesized and evaluated for their EGFR/HER-2 inhibitory and anti-proliferation activities. Compound D14 displayed the most potent activity against EGFR and A549 cell line (IC(50)=0.05 μM and GI(50)=0.11 μM), being comparable with the positive control Erlotinib (IC(50)=0.03 μM and GI(50)=0.03 μM) and more potent than our previous compounds C0-A...
Paper Details
Title
Design, modification and 3D QSAR studies of novel naphthalin-containing pyrazoline derivatives with/without thiourea skeleton as anticancer agents
Published Date
Mar 1, 2013
Volume
21
Issue
5
Pages
1050 - 1063
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