Characterization of a novel brain barrier ex vivo insect‐based P‐glycoprotein screening model
Abstract
In earlier studies insects were proposed as suitable models for vertebrate blood-brain barrier (BBB) permeability prediction and useful in early drug discovery. Here we provide transcriptome and functional data demonstrating the presence of a P-glycoprotein (Pgp) efflux transporter in the brain barrier of the desert locust (Schistocerca gregaria). In an in vivo study on the locust, we found an increased uptake of the two well-known Pgp...
Paper Details
Title
Characterization of a novel brain barrier ex vivo insect‐based P‐glycoprotein screening model
Published Date
Jun 9, 2014
Volume
2
Issue
4
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