Original paper

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

Science44.70
Volume: 269, Issue: 5223, Pages: 540 - 543
Published: Jul 28, 1995
Abstract
C57BL/6J mice with a mutation in the obese (ob) gene are obese, diabetic, and exhibit reduced activity, metabolism, and body temperature. Daily intraperitoneal injection of these mice with recombinant OB protein lowered their body weight, percent body fat, food intake, and serum concentrations of glucose and insulin. In addition, metabolic rate, body temperature, and activity levels were increased by this treatment. None of these parameters was...
Paper Details
Title
Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice
Published Date
Jul 28, 1995
Journal
Volume
269
Issue
5223
Pages
540 - 543
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