Influence of hepatocyte nuclear factor 4α (HNF4α) gene variants on the risk of type 2 diabetes: A meta-analysis in 49,577 individuals
Abstract
The nuclear receptor hepatocyte nuclear factor 4α (HNF4α) contributes to the regulation of a large fraction of liver and pancreatic islet transcriptomes. To evaluate the influence of HNF4α polymorphisms across the entire locus on the occurrence of type 2 diabetes (T2D) by means of a meta-analysis. We evaluated haplotype block structure of HNF4α variants owing to linkage disequilibrium (LD). From 1455 reports, we evaluated 21 observational...
Paper Details
Title
Influence of hepatocyte nuclear factor 4α (HNF4α) gene variants on the risk of type 2 diabetes: A meta-analysis in 49,577 individuals
Published Date
Jan 1, 2010
Volume
99
Issue
1
Pages
80 - 89
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