Novel Mechanism of Chronic Exposure of Oleic Acid-Induced Insulin Release Impairment in Rat Pancreatic beta-Cells

Abstract
A sustained, high circulating level of free fatty acids (FFAs) is an important risk factor for the development of insulin resistance, islet beta-cell dysfunction, and pathogenesis of type 2 diabetes. Here, we report a novel mechanism of chronic exposure of oleic acid (OA)-induced rat insulin release impairment. Following a 4-day exposure to 0.1 mM OA, there was no significant difference in basal insulin release when comparing OA-treated and...
Paper Details
Title
Novel Mechanism of Chronic Exposure of Oleic Acid-Induced Insulin Release Impairment in Rat Pancreatic beta-Cells
Published Date
May 23, 2006
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