Cas9 specifies functional viral targets during CRISPR–Cas adaptation
Abstract
Clustered regularly interspaced short palindromic repeat (CRISPR) loci and their associated (Cas) proteins provide adaptive immunity against viral infection in prokaryotes. Upon infection, short phage sequences known as spacers integrate between CRISPR repeats and are transcribed into small RNA molecules that guide the Cas9 nuclease to the viral targets (protospacers). Streptococcus pyogenes Cas9 cleavage of the viral genome requires the...
Paper Details
Title
Cas9 specifies functional viral targets during CRISPR–Cas adaptation
Published Date
Feb 18, 2015
Journal
Volume
519
Issue
7542
Pages
199 - 202
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