No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans
Abstract
Non-African populations have experienced size reductions in the time since their split from West Africans, leading to the hypothesis that natural selection to remove weakly deleterious mutations has been less effective in the history of non-Africans. To test this hypothesis, we measured the per-genome accumulation of nonsynonymous substitutions across diverse pairs of populations. We find no evidence for a higher load of deleterious mutations in...
Paper Details
Title
No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans
Published Date
Jan 12, 2015
Journal
Volume
47
Issue
2
Pages
126 - 131
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