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No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans

Published on Feb 1, 2015in Nature Genetics25.455
· DOI :10.1038/ng.3186
Ron Do39
Estimated H-index: 39
,
Daniel J. Balick7
Estimated H-index: 7
+ 3 AuthorsDavid Reich109
Estimated H-index: 109
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Abstract
David Reich, Shamil Sunyaev and colleagues report an analysis of the per-genome accumulation of nonsynonymous substitutions across diverse pairs of human populations. They find no evidence for a higher load of deleterious mutations in non-Africans than in West Africans and show that the observed patterns are not likely to reflect changes in natural selection.
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