Reduced striatal ecto-nucleotidase activity in schizophrenia patients supports the “adenosine hypothesis”
Abstract
Schizophrenia (SZ) is a major chronic neuropsychiatric disorder characterized by a hyperdopaminergic state. The hypoadenosinergic hypothesis proposes that reduced extracellular adenosine levels contribute to dopamine D2 receptor hyperactivity. ATP, through the action of ecto-nucleotidases, constitutes a main source of extracellular adenosine. In the present study, we examined the activity of ecto-nucleotidases (NTPDases, ecto-5'-nucleotidase,...
Paper Details
Title
Reduced striatal ecto-nucleotidase activity in schizophrenia patients supports the “adenosine hypothesis”
Published Date
Jun 16, 2013
Journal
Volume
9
Issue
4
Pages
599 - 608
Citation AnalysisPro
You’ll need to upgrade your plan to Pro
Looking to understand the true influence of a researcher’s work across journals & affiliations?
- Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
- Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.
Notes
History