Lysosome-mediated processing of chromatin in senescence
Abstract
Cellular senescence is a stable proliferation arrest, a potent tumor suppressor mechanism, and a likely contributor to tissue aging. Cellular senescence involves extensive cellular remodeling, including of chromatin structure. Autophagy and lysosomes are important for recycling of cellular constituents and cell remodeling. Here we show that an autophagy/lysosomal pathway processes chromatin in senescent cells. In senescent cells, lamin...
Paper Details
Title
Lysosome-mediated processing of chromatin in senescence
Published Date
Jul 1, 2013
Journal
Volume
202
Issue
1
Pages
129 - 143
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