The G-Protein-Coupled Long-Chain Fatty Acid Receptor GPR40 and Glucose Metabolism

Free fatty acids (FFAs) play a pivotal role in metabolic control and cell signaling processes in various tissues. In particular, FFAs are known to augment glucose-stimulated insulin secretion (GSIS) by pancreatic beta cells, where fatty acid-derived metabolites, such as long chain fatty acyl-CoAs, are believed to act as crucial effectors. Recently, G-protein-coupled receptor 40 (GPR40), a receptor for long-chain fatty acids, was reported to be...