On the Mechanism of Membrane Protein Crystallization in Lipidic Mesophases
Abstract
The in meso method for crystallizing membrane proteins has been shown to work with a range of different protein types. The method involves reconstituting the target protein into the bilayer of a bicontinuous lipid mesophase followed by an induced phase separation brought on by the addition of a precipitant. A mechanism has been proposed for how in meso crystallogenesis comes about at a molecular level. However, aspects of the hypothesis are not...
Paper Details
Title
On the Mechanism of Membrane Protein Crystallization in Lipidic Mesophases
Published Date
Nov 14, 2008
Journal
Volume
8
Issue
12
Pages
4244 - 4254
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