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doi.org/10.1073/pnas.0711183105

Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse

..., Masanori Hatakeyama
50
Proceedings of the National Academy of Sciences of the United States of America11.10
Volume: 105, Issue: 3, Pages: 1003 - 1008
Published: Jan 22, 2008
Abstract
Infection with cagA -positive Helicobacter pylori is associated with gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue (MALT) lymphoma of B cell origin. The cagA -encoded CagA protein is delivered into gastric epithelial cells via the bacterial type IV secretion system and, upon tyrosine phosphorylation by Src family kinases, specifically binds to and aberrantly activates SHP-2 tyrosine phosphatase, a bona fide oncoprotein in...
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Paper Details
Title
Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse
DOI
doi.org/10.1073/pnas.0711183105
Published Date
Jan 22, 2008
Journal
Proceedings of the National Academy of Sciences of the United States of America
Volume
105
Issue
3
Pages
1003 - 1008
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