Correction of a Genetic Disease in Mouse via Use of CRISPR-Cas9
Abstract
The CRISPR-Cas9 system has been employed to generate mutant alleles in a range of different organisms. However, so far there have not been reports of use of this system for efficient correction of a genetic disease. Here we show that mice with a dominant mutation in Crygc gene that causes cataracts could be rescued by coinjection into zygotes of Cas9 mRNA and a single-guide RNA (sgRNA) targeting the mutant allele. Correction occurred via...
Paper Details
Title
Correction of a Genetic Disease in Mouse via Use of CRISPR-Cas9
Published Date
Dec 1, 2013
Journal
Volume
13
Issue
6
Pages
659 - 662
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