Thrombocytopenia, Giant Platelets, and Leukocyte Inclusion Bodies (May-Hegglin Anomaly): Clinical and Laboratory Findings

Purpose: May-Hegglin anomaly is a rare hereditary condition characterized by the triad of thrombocytopenia, giant platelets, and inclusion bodies in leukocytes. Clinical features and the pathogenesis of bleeding in this disease are poorly defined. Patients and Methods: From 1988 to 1996 we studied 15 new May-Hegglin anomaly patients from 7 unrelated Italian families. In addition to clinical examination and routine laboratory testing, we measured...