The Decline of Autophagy Contributes to Proximal Tubular Dysfunction During Sepsis
Abstract
Severe sepsis associated with overproduction of tumor necrosis factor α and reactive oxygen species leads to energy depletion and cellular damage. Both reactive oxygen species and damaged organelles induce autophagy for recycling nutrients to combat pathological stress. To study whether autophagy plays a beneficial role in the pathogenesis of renal failure during sepsis, rats were subjected to cecal ligation and puncture (CLP) or sham operation....
Paper Details
Title
The Decline of Autophagy Contributes to Proximal Tubular Dysfunction During Sepsis
Published Date
Mar 1, 2012
Journal
Volume
37
Issue
3
Pages
289 - 296
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Notes
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