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Cover Picture: The Crystal Structure of Human α2‐Macroglobulin Reveals a Unique Molecular Cage (Angew. Chem. Int. Ed. 14/2012)

Published on Apr 2, 2012in Angewandte Chemie12.257
· DOI :10.1002/anie.201109104
A. Marrero8
Estimated H-index: 8
(CSIC: Spanish National Research Council),
Stéphane Duquerroy21
Estimated H-index: 21
(University of Paris-Sud)
+ 6 AuthorsF. Xavier Gomis-Rüth31
Estimated H-index: 31
(CSIC: Spanish National Research Council)
Abstract
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  • Citations (1)
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#1David Neves (CNRS: Centre national de la recherche scientifique)H-Index: 6
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α2 macroglobulins (α2Ms) are broad-spectrum protease inhibitors that play essential roles in the innate immune system of eukaryotic species. These large, multi-domain proteins are characterized by a broad-spectrum bait region and an internal thioester, which, upon cleavage, becomes covalently associated to the target protease, allowing its entrapment by a large conformational modification. Notably, α2Ms are part of a larger protein superfamily that includes proteins of the complement system, suc...
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