Reassessment of Glucose Effectiveness and Insulin Sensitivity From Minimal Model Analysis: A Theoretical Evaluation of the Single-Compartment Glucose Distribution Assumption

Minimal model analysis with the frequently sampled intravenous glucose tolerance test provides an effective way to measure two important metabolic parameters in vivo under non-steady-state conditions: glucose effectiveness (SG) and insulin sensitivity (SI). Two questions regarding the validity of SG and SI have recently emerged. First, SG from the minimal model is suspected to be overestimated. Second, the occurrence of SI values...