hydrate formation

neurodegenerative diseases

glutamate-induced

barrier discharge

neuroprotective_79526

zn-air

pulmonary_118596

neuroprotective_109164

neuroprotective_45065

population genetic

predictive controller

memory impairment

alzheimer_83055

glutamate release

qcd sum

soil microbes

gonorrhea

Biomedicine & Preventive Nutrition

To evaluate the anti-amnesic and neuroprotective activity of ethanolic extract of Prunus avium (EEPA) on streptozotocin (STZ) induced neurotoxicity in mice. The mice were pre-treated with EEPA at selective doses (200, 400 mg/kg, p.o.) for a period of 3 weeks followed by intracerebroventricular injection (ICV) of STZ (0.5 mg/kg). Neurobehavioral-alterations were evaluated using Y-maze and elevated plus maze. Biochemical markers , such as acetylcholinesterase (AChE), corticosterone , thiobarbituric reactive substances (TBARS), tissue nitrite, antioxidants, such as superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase were estimated. Obtain results revealed those 28 days of treatment with EEPA was effective in averting neurotoxicity. EEPA supplementation significantly reduced AChE, corticosterone, TBARS, tissue nitrite levels and ameliorated the deficits in learning and memory impairment with increased levels of antioxidants. These results envisage that ethanolic extract of Prunus avium exhibit cognitive improvement which is most likely related, at least in part, to its antioxidant and neuroprotective activity. Further studies are suggested to evaluate the isolated bioactive Prunus avium fruits to identify the molecular mechanism involved in modulation of cholinergic transmission.

Neuroprotective effect of Prunus avium on streptozotocin induced neurotoxicity in mice