Neuroprotection

Neuroscience

Biology

Streptozotocin

Endocrinology

Biochemistry

Botany

Glutathione

Glutathione peroxidase

TBARS

Organic chemistry

Superoxide dismutase

Toxicity

Lipid peroxidation

Antioxidant

Neurotoxicity

Enzyme

Pharmacology

Prunus

Medicine

Chemistry

Acetylcholinesterase

Traditional medicine

Diabetes mellitus

Biomedicine & Preventive Nutrition

Objective null To evaluate the anti-amnesic and neuroprotective activity of ethanolic extract of null Prunus avium null (EEPA) on streptozotocin (STZ) induced neurotoxicity in mice. null null null Methods null The mice were pre-treated with EEPA at selective doses (200, 400 mg/kg, p.o.) for a period of 3 weeks followed by intracerebroventricular injection (ICV) of STZ (0.5 mg/kg). Neurobehavioral-alterations were evaluated using Y-maze and elevated plus maze. Biochemical markers, such as acetylcholinesterase (AChE), corticosterone, thiobarbituric reactive substances (TBARS), tissue nitrite, antioxidants, such as superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase were estimated. null null null Results null Obtain results revealed those 28 days of treatment with EEPA was effective in averting neurotoxicity. EEPA supplementation significantly reduced AChE, corticosterone, TBARS, tissue nitrite levels and ameliorated the deficits in learning and memory impairment with increased levels of antioxidants. null null null Conclusions null These results envisage that ethanolic extract of null Prunus avium null exhibit cognitive improvement which is most likely related, at least in part, to its antioxidant and neuroprotective activity. Further studies are suggested to evaluate the isolated bioactive null Prunus avium null fruits to identify the molecular mechanism involved in modulation of cholinergic transmission.

Neuroprotective effect of Prunus avium on streptozotocin induced neurotoxicity in mice