Dynamic Regulatory Interactions of Rad51, Rad52, and Replication Protein-A in Recombination Intermediates
Abstract
Rad51, Rad52, and replication protein-A (RPA) play crucial roles in the repair of DNA double-strand breaks in Saccharomyces cerevisiae. Rad51 mediates DNA strand exchange, a key reaction in DNA recombination. Rad52 recruits Rad51 into single-stranded DNAs (ssDNAs) that are saturated with RPA. Rad52 also promotes annealing of ssDNA strands that are complexed with RPA. Specific protein-protein interactions are involved in these reactions. Here we...
Paper Details
Title
Dynamic Regulatory Interactions of Rad51, Rad52, and Replication Protein-A in Recombination Intermediates
Published Date
Jul 1, 2009
Journal
Volume
390
Issue
1
Pages
45 - 55
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