The human peptidylarginine deiminases type 2 and type 4 have distinct substrate specificities
Volume: 1844, Issue: 4, Pages: 829 - 836
Published: Apr 1, 2014
Abstract
Human peptidylarginine deiminases (hPADs) have been implicated in several diseases, particularly in rheumatoid arthritis. Since hPAD2 and hPAD4 are the isotypes expressed in the inflamed joints of RA patients and protein citrullination by PADs has been proposed to play a pathophysiological role, they represent unique therapeutic targets. To facilitate the development of substrate-based PAD inhibitors the substrate specificity of hPAD2 and hPAD4...
Paper Details
Title
The human peptidylarginine deiminases type 2 and type 4 have distinct substrate specificities
Published Date
Apr 1, 2014
Volume
1844
Issue
4
Pages
829 - 836
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