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Insulin Resistance in Aging Is Related to Abdominal Obesity
Published on Feb 1, 1993in Diabetes 7.27
· DOI :10.2337/diab.42.2.273
Wendy M. Kohrt31
Estimated H-index: 31
(Washington University in St. Louis),
John P Kirwan5
Estimated H-index: 5
(Washington University in St. Louis)
+ 3 AuthorsJohn O. Holloszy110
Estimated H-index: 110
(Washington University in St. Louis)
Studies have shown that insulin resistance increases with age, independent of changes in total adiposity. However, there is growing evidence that the development of insulin resistance may be more closely related to abdominal adiposity. To evaluate the independent effects of aging and regional and total adiposity on insulin resistance, we performed hyperinsulinemic euglycemic clamps on 17 young (21–33 yr) and 67 older (60–72 yr) men and women. We assessed FFM and total and regional adiposity by hydrodensitometry and anthropometry. Insulin-stimulated GORs at a plasma insulin concentration of ∼450 pM averaged 45.6 ± 3.3 μmol · kg FFM −1 · min −1 (mean ± SE) in the young subjects, 45.6 ± 10.0 μmol · kg FFM −1 · min −1 in 24 older subjects who were insulin sensitive, and 23.9 ± 11.7 μmol · kg FFM −1 · min −1 in 43 older subjects who were insulin resistant. Few significant differences were apparent in skin-fold and circumference measurements between young and insulin-sensitive older subjects, but measurements at most central body sites were significantly larger in the insulin-resistant older subjects. Waist girth accounted for >40% of the variance in insulin action, whereas age explained only 10–20% of the total variance and
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Cited By243
Published on Jan 1, 2014
Mira Aubuchon8
Estimated H-index: 8
(University of Missouri),
Jennifer A. Bickhaus (University of Missouri), Frank González15
Estimated H-index: 15
(Indiana University)
Obesity has grown in pandemic proportions with modern dietary habits and sedentary lifestyle as likely contributors. More recently, epigenetic phenomena have been implicated in the development of obesity. Beyond its energy-storing capacity, the adipose tissue acts as an endocrine and immunological organ. Accumulation of excess adiposity causes dysfunction of the adipose tissue compartment. This dysfunction ultimately leads to immune alterations characterized by inflammation, which then cause met...
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Published on Jan 1, 2003
Cardiovascular disease, and in particular coronary heart disease, is the predominant cause of death and disability worldwide in populations older than 65 yr of age; about half of elderly individuals in industrialized countries have clinical evidence of coronary heart disease. The World Health Organization (WHO) Study Group report on the epidemiology and prevention of cardiovascular diseases in elderly people (1) identified coronary heart disease as the major cause of mortality in industrialized ...
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Published on Jan 1, 2013
Réjeanne Gougeon20
Estimated H-index: 20
(McGill University)
Population studies show an increased risk for diabetes with obesity, notably abdominal obesity. This risk is further aggravated by sedentary lifestyle and exposure to undernutrition in utero. Maternal obesity also alters fetal growth and development, leading to a larger baby prone to diabetes in adulthood. It is recommended to avoid excessive weight gains in pregnancy. The best predictor of type 2 diabetes in obesity is a concurrent insulin resistance and associated hyperinsulinemia with decreas...
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Published on Jan 1, 2004
Roger B. McDonald25
Estimated H-index: 25
Rodney C. Ruhe6
Estimated H-index: 6
Biologic aging is a complex and multifactoral phenomenon that is not well understood. Deficiencies in our understanding of the aging process are particularly evident with regard to the interface between normal deteriorative changes observed in all individuals (e.g., gray hair, loss of muscle mass, etc.) and clear, definable disease (e.g., cancer, Alzheimer’ s disease, etc.). For example, what factors contribute to the progression of the age-related dysregulation of glucose homeostasis into type ...
1 Citations Source Cite
Published on Jan 1, 2005in Diabetic Medicine 3.13
Qing Qiao45
Estimated H-index: 45
J. Tuomilehto39
Estimated H-index: 39
+ 3 AuthorsNicholas J. Wareham155
Estimated H-index: 155
21 Citations Source Cite
Published on Jan 1, 2000
Obesity is considered to be the major nutritional disorder in many countries of the industrialized world. The physiology of the obese and their propensity for chronic disease has been of growing interest over the past few years. Overweight persons are at increased risk of coronary artery disease, arterial hypertension, and cancer. There is also a profound association between obesity, particularly intraabdominal adiposity, and the development of non-insulin-dependent diabetes mellitus (NIDDM). Ob...
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Published on Jan 1, 2001
Published on May 9, 2012
Mara Patrícia Traina Chacon-Mikahil11
Estimated H-index: 11
(State University of Campinas),
Cleiton Augusto Libardi12
Estimated H-index: 12
(State University of Campinas)
+ 4 AuthorsVera Aparecida Madruga7
Estimated H-index: 7
(State University of Campinas)
O objetivo do estudo foi analisar as adaptacoes morfofuncionais decorrentes de 12 semanas de treinamento concorrente (TC). Quinze homens saudaveis, sedentarios, de meia-idade (48,8 ± 5,0 anos) participaram deste estudo. Foram separados em: grupo treinamento concorrente (TC, n=8), que realizaram exercicios com pesos seguidos de exercicios de caminhada e corrida; e grupo controle (GC, n=7), o qual nao realizou exercicios fisicos durante o periodo experimental. Foram realizadas avaliacoes antropome...
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Published on Jan 1, 2011in Comprehensive Physiology 5.80
Dariush Elahi1
Estimated H-index: 1
(University of Maryland, Baltimore),
Marianne McAloon Dyke1
Estimated H-index: 1
(University of Maryland, Baltimore),
Reubin Andres (University of Maryland, Baltimore)
The sections in this article are: 1 Fat Mass 1.1 Direct Methods of Measuring Fat Mass 1.2 Indirect Methods of Measuring Fat Mass 1.3 Measurement of Body Fat Distribution 1.4 Recommendations on Fat Mass Measurements 2 Adiposity and Age-Associated Diseases 2.1 Glucose Intolerance 2.2 Obesity 2.3 Serum lipoproteins and Atherosclerosis
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View next paperRole of Body Fat Distribution in the Decline in Insulin Sensitivity and Glucose Tolerance with Age