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Insulin Resistance in Aging Is Related to Abdominal Obesity

Published on Feb 1, 1993in Diabetes 7.27
· DOI :10.2337/diab.42.2.273
Wendy M. Kohrt60
Estimated H-index: 60
(Washington University in St. Louis),
John P. Kirwan54
Estimated H-index: 54
(Washington University in St. Louis)
+ 3 AuthorsJohn O. Holloszy93
Estimated H-index: 93
(Washington University in St. Louis)
Abstract
Studies have shown that insulin resistance increases with age, independent of changes in total adiposity. However, there is growing evidence that the development of insulin resistance may be more closely related to abdominal adiposity. To evaluate the independent effects of aging and regional and total adiposity on insulin resistance, we performed hyperinsulinemic euglycemic clamps on 17 young (21–33 yr) and 67 older (60–72 yr) men and women. We assessed FFM and total and regional adiposity by hydrodensitometry and anthropometry. Insulin-stimulated GORs at a plasma insulin concentration of ∼450 pM averaged 45.6 ± 3.3 μmol · kg FFM −1 · min −1 (mean ± SE) in the young subjects, 45.6 ± 10.0 μmol · kg FFM −1 · min −1 in 24 older subjects who were insulin sensitive, and 23.9 ± 11.7 μmol · kg FFM −1 · min −1 in 43 older subjects who were insulin resistant. Few significant differences were apparent in skin-fold and circumference measurements between young and insulin-sensitive older subjects, but measurements at most central body sites were significantly larger in the insulin-resistant older subjects. Waist girth accounted for >40% of the variance in insulin action, whereas age explained only 10–20% of the total variance and
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Published on May 14, 2019in Cochrane Database of Systematic Reviews 6.75
Rebecca J Griffith1
Estimated H-index: 1
(University of Auckland),
Jane M. Alsweiler11
Estimated H-index: 11
(University of Auckland)
+ 4 AuthorsCaroline A Crowther60
Estimated H-index: 60
(University of Auckland)
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Published on Apr 1, 2019
Yuehan Wang (Radboud University Nijmegen), Duck-chul Lee29
Estimated H-index: 29
(Iowa State University)
+ 4 AuthorsSteven N. Blair140
Estimated H-index: 140
(University of South Carolina)
Abstract Objective To examine the association between muscular strength and incident type 2 diabetes, independent of cardiorespiratory fitness (CRF). Patients and Methods A total of 4681 adults aged 20 to 100 years who had no type 2 diabetes at baseline were included in the current prospective cohort study. Participants underwent muscular strength tests and maximal treadmill exercise tests between January 1, 1981, and December 31, 2006. Muscular strength was measured by leg and bench press and c...
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Published on Mar 12, 2019in International Journal of Molecular Sciences 3.69
Ditte Søgaard4
Estimated H-index: 4
,
Marcin Baranowski20
Estimated H-index: 20
+ 6 AuthorsJørn Wulff Helge39
Estimated H-index: 39
Ceramide and diacylglycerol are linked to insulin resistance in rodents, but in humans the data are inconsistent. Insulin resistance is frequently observed with aging, but the role of ceramide and diacylglycerol is not clarified. Training improves metabolic health and, therefore, we aimed to elucidate the influence of age and high-intensity interval training (HIIT) on ceramide and diacylglycerol content in muscle. Fourteen young (33 ± 1) and 22 older (63 ± 1) overweight to obese subjects perform...
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Published on Dec 1, 2018in Scientific Reports 4.12
Zuzana Novosadová2
Estimated H-index: 2
(Charles University in Prague),
Lenka Polidarová11
Estimated H-index: 11
+ 1 AuthorsAlena Sumová26
Estimated H-index: 26
The physiological function of the pancreas is controlled by the circadian clock. The aim of this study was to determine whether aging-induced changes in glucose homeostasis affect properties of the circadian clock in the pancreas and/or its sensitivity to disturbances in environmental lighting conditions. mPer2Luc mice aged 24–26 months developed hyperinsulinemic hypoglycaemia, which was likely due to the Pclo-mediated insulin hyper-secretion and Slc2a2-mediated glucose transport impairment in t...
1 Citations Source Cite
Published on Jun 13, 2018in Journal of Parkinson's disease
Elliot Hogg1
Estimated H-index: 1
(Cedars-Sinai Medical Center),
Kishore Athreya1
Estimated H-index: 1
(Cedars-Sinai Medical Center)
+ 3 AuthorsMichele Tagliati17
Estimated H-index: 17
(Cedars-Sinai Medical Center)
1 Citations Source Cite
Published on Apr 1, 2018in Acta Physiologica 5.93
Ditte Søgaard4
Estimated H-index: 4
(University of Copenhagen),
M. T. Lund4
Estimated H-index: 4
(University of Copenhagen)
+ 9 AuthorsAndreas Vigelsø8
Estimated H-index: 8
(University of Copenhagen)
14 Citations Source Cite
Published on Apr 1, 2018in Trends in Pharmacological Sciences 12.11
Agata Bielecka-Dabrowa13
Estimated H-index: 13
(Medical University of Łódź),
Jaroslaw Fabis5
Estimated H-index: 5
(Medical University of Łódź)
+ 4 AuthorsMaciej Banach44
Estimated H-index: 44
(University of Zielona Góra)
Some studies using small doses of statins revealed significant benefits for patients with chronic heart failure (HF). However, the results of large randomized studies did not confirm these advantages. Along with the primary effect of cholesterol lowering, statins have many ancillary actions that may be relevant for body wasting. In this context, the fear of muscle-related side effects needs to be put into clinical context and assessed appropriately before statins are either withheld or withdrawn...
4 Citations Source Cite
Published on Feb 23, 2018in Comparative Exercise Physiology
R.C. Avenatti1
Estimated H-index: 1
(Rutgers University),
Kenneth H. McKeever29
Estimated H-index: 29
(Rutgers University)
+ 1 AuthorsK. Malinowski15
Estimated H-index: 15
(Rutgers University)
We hypothesised that the cortisol response to acute exercise, markers of oxidative stress, expression of inflammatory cytokines, heat shock protein (HSP)70 and HSP90 expression in whole blood and skeletal muscle, and HSP70 and HSP90 protein concentrations in skeletal muscle are altered by age and in response to acute submaximal exercise in horses. Young (n=6; 5.5±2.8 year) and aged (n=6; 22.6±2.25 year) unconditioned Standardbred mares underwent an acute submaximal exercise test. Blood samples w...
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Carlos H. Orces3
Estimated H-index: 3
,
Martha Montalván4
Estimated H-index: 4
(University of Guayaquil),
Daniel Tettamanti4
Estimated H-index: 4
(Catholic University of Santiago de Guayaquil)
Abstract Aims To describe the prevalence of abdominal obesity and its association with cardio metabolic risk factors among older adults in Ecuador. Materials and methods The present study used data from the National Survey of Health, Wellbeing, and Aging survey to examine the prevalence of abdominal obesity according to certain demographic, behavioral, and health characteristics of the participants. Logistic regression models adjusted for potential confounders were used to evaluate the associati...
3 Citations Source Cite
Published on Oct 1, 2017in Indian heart journal
Rajesh Kumar Goit3
Estimated H-index: 3
,
Bhawana Neupane Pant1
Estimated H-index: 1
,
Mukesh Kumar Shrewastwa1
Estimated H-index: 1
Abstract Aim The aim of this study was to determine the effect of moderate aerobic exercise on heart rate variability (HRV) in obese adults with type 2 diabetes. Methods Forty-one obese adults with type 2 diabetes participated in this study. Anthropometric and metabolic parameters were measured, and resting electrocardiogram (ECG) for the HRV analysis at spontaneous respiration was recorded for 5 min in supine position before and after six months of supervised aerobic training given thrice-a-wee...
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