Release Kinetics of 6-Mercaptopurine and 6-Thioguanine from Bioinspired Core-Crosslinked Thymine Functionalised Polymeric Micelles

A bioinspired core-bound polymeric micellar system based on hydrogen bonding and photo-crosslinking of thymine has been prepared from the amphiphilic block copolymers, poly(vinylbenzylthymine)-block-poly(vinylbenzyltriethylammonium chloride). The chemical loading and controlled release potential of these micelles was investigated using two drugs, 6-mercaptopurine and 6-thioguanine. The release kinetics of drug-loaded polymeric micelles was...