Oral l -Arginine in Patients With Coronary Artery Disease on Medical Management

Vascular nitric oxide (NO) bioavailability is reduced in patients with coronary artery disease (CAD). We investigated whether oral L-arginine, the substrate for NO synthesis, improves homeostatic functions of the vascular endothelium in patients maintained on appropriate medical therapy and thus might be useful as adjunctive therapy.Thirty CAD patients (29 men; age, 67+/-8 years) on appropriate medical management were randomly assigned to...