Generation of knockout mice using engineered nucleases
Abstract
The use of engineered nucleases in one-cell stage mouse embryos is emerging as an efficient alternative to conventional gene targeting in mouse embryonic stem (ES) cells. These nucleases are designed or reprogrammed to specifically induce double strand breaks (DSBs) at a desired genomic locus, and efficiently introduce mutations by both error-prone and error-free DNA repair mechanisms. Since these mutations frequently result in the loss or...
Paper Details
Title
Generation of knockout mice using engineered nucleases
Published Date
Aug 1, 2014
Journal
Volume
69
Issue
1
Pages
85 - 93
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