Somatic expression of LINE-1 elements in human tissues
Abstract
LINE-1 expression damages host DNA via insertions and endonuclease-dependent DNA double-strand breaks (DSBs) that are highly toxic and mutagenic. The predominant tissue of LINE-1 expression has been considered to be the germ line. We show that both full-length and processed L1 transcripts are widespread in human somatic tissues and transformed cells, with significant variation in both L1 expression and L1 mRNA processing. This is the first...
Paper Details
Title
Somatic expression of LINE-1 elements in human tissues
Published Date
Mar 9, 2010
Journal
Volume
38
Issue
12
Pages
3909 - 3922
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