Mitogen-activated protein kinase activation induces corticotrophin-releasing hormone gene expression in human placenta
Abstract
Corticotropin-releasing hormone (CRH) gene expression in human placental cells is induced by activation of the cyclic AMP and protein kinase C signal transduction pathways, but the role of the mitogen-activated kinase (MAPK) pathway is unknown. In this study, we showed that the MAPK inhibitor, PD098059, causes a dose-dependent inhibition of placental CRH gene expression. In contrast, overexpression of RAF in human choriocarcinoma JEG cells...
Paper Details
Title
Mitogen-activated protein kinase activation induces corticotrophin-releasing hormone gene expression in human placenta
Published Date
Jul 1, 2005
Journal
Volume
77
Issue
11
Pages
1263 - 1272
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