α1-Antitrypsin Therapy Downregulates Toll-Like Receptor-Induced IL-1β Responses in Monocytes and Myeloid Dendritic Cells and May Improve Islet Function in Recently Diagnosed Patients With Type 1 Diabetes
Volume: 99, Issue: 8, Pages: E1418 - E1426
Published: Aug 1, 2014
Abstract
Recent studies have implicated proinflammatory responses in the mechanism of type 1 diabetes (T1D). Our objective was to evaluate the safety and effects of therapy with the anti-inflammatory serum protein α1-antitrypsin (AAT) on islet function and innate immunity in recent-onset patients. This was an open-label phase I trial at the Barbara Davis Center for Childhood Diabetes, University of Colorado Denver. Twelve recently diagnosed subjects with...
Paper Details
Title
α1-Antitrypsin Therapy Downregulates Toll-Like Receptor-Induced IL-1β Responses in Monocytes and Myeloid Dendritic Cells and May Improve Islet Function in Recently Diagnosed Patients With Type 1 Diabetes
Published Date
Aug 1, 2014
Volume
99
Issue
8
Pages
E1418 - E1426
Citation AnalysisPro
You’ll need to upgrade your plan to Pro
Looking to understand the true influence of a researcher’s work across journals & affiliations?
- Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
- Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.
Notes
History