Polymeric Precipitants for the Crystallization of Macromolecules

Nine different water soluble polymers reported to strongly affect the properties and structure of water were evaluated for their use in crystallizing a series of 24 different proteins, viruses, and conventional small molecules. All of the polymers produced crystals of some of the molecules and viruses tested, and of the 24 molecules tested, 14 were crystallized. In a number of cases, crystals of the molecules and viruses were obtained under very...