Evidence for tangeretinO-demethylation by rat and human liver microsomes

Volume: 23, Issue: 3, Pages: 259 - 266
Published: Jan 1, 1993
Abstract
1. Tangeretin, a polymethoxylated flavone, was studied as a substrate for cytochrome P450-catalysed demethylation reactions by rat and human liver microsomes. Evidence has been presented for the production of formaldehyde in the presence of tangeretin and NAD(P)H. Kinetic studies showed a Km value for tangeretin of about 18 μmlM in both species.2. The reaction was inhibited by CO, piperonyl butoxide, 7,8-benzoflavone, propyl gallate,...
Paper Details
Title
Evidence for tangeretinO-demethylation by rat and human liver microsomes
Published Date
Jan 1, 1993
Volume
23
Issue
3
Pages
259 - 266
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