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Saguenay Youth Study: A multi-generational approach to studying virtual trajectories of the brain and cardio-metabolic health

Published on Feb 1, 2015in Developmental Cognitive Neuroscience4.92
· DOI :10.1016/j.dcn.2014.10.003
Tomáš Paus82
Estimated H-index: 82
(U of T: University of Toronto),
Zdenka Pausova41
Estimated H-index: 41
(U of T: University of Toronto)
+ 4 AuthorsLouis Richer30
Estimated H-index: 30
(Université du Québec)
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Abstract
This paper provides an overview of the Saguenay Youth Study (SYS) and its parental arm. The overarching goal of this effort is to develop trans-generational models of developmental cascades contributing to the emergence of common chronic disorders, such as depression, addictions, dementia and cardio-metabolic diseases. Over the past 10 years, we have acquired detailed brain and cardio-metabolic phenotypes, and genome-wide genotypes, in 1029 adolescents recruited in a population with a known genetic founder effect. At present, we are extending this dataset to acquire comparable phenotypes and genotypes in the biological parents of these individuals. After providing conceptual background for this work (transactions across time, systems and organs), we describe briefly the tools employed in the adolescent arm of this cohort and highlight some of the initial accomplishments. We then outline in detail the phenotyping protocol used to acquire comparable data in the parents.
  • References (111)
  • Citations (12)
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References111
Newest
Published on Dec 1, 2014in NeuroImage5.81
Deborah H. Schwartz6
Estimated H-index: 6
(U of T: University of Toronto),
Erin Dickie7
Estimated H-index: 7
+ 7 AuthorsTomáš Paus82
Estimated H-index: 82
(U of T: University of Toronto)
Abstract Obesity, a major risk factor for cardiometabolic disease, is associated with variations in a number of structural properties in the adult brain, as assessed with magnetic resonance imaging (MRI). In this study, we investigated the cross-sectional relationship between visceral fat (VF), total body fat (TBF) and three MRI parameters in the brains of typically developing adolescents: (i) T1-weighted (T1W) signal intensity; (ii) T1W signal contrast between white matter (WM) and gray matter ...
Published on Jan 1, 2014in NeuroImage5.81
Douglas C. Dean13
Estimated H-index: 13
(Brown University),
Jonathan O'Muircheartaigh22
Estimated H-index: 22
(Brown University)
+ 5 AuthorsSean C.L. Deoni33
Estimated H-index: 33
(Brown University)
An emerging hypothesis in developmental and behavioral disorders is that they arise from disorganized brain messaging or reduced connectivity. Given the importance of myelin to efficient brain communication, characterization of myelin development in infancy and childhood may provide salient information related to early connectivity deficits. In this work, we investigate regional and whole brain growth trajectories of the myelin water fraction, a quantitative magnetic resonance imaging measure se...
Published on Jan 1, 2014in Molecular Psychiatry11.97
A. Haghighi1
Estimated H-index: 1
,
Melkaye G. Melka5
Estimated H-index: 5
+ 12 AuthorsCelia Greenwood27
Estimated H-index: 27
Dietary preference for fat may increase risk for obesity. It is a complex behavior regulated in part by the amygdala, a brain structure involved in reward processing and food behavior, and modulated by genetic factors. Here, we conducted a genome-wide association study (GWAS) to search for gene loci associated with dietary intake of fat, and we tested whether these loci are also associated with adiposity and amygdala volume. We studied 598 adolescents (12–18 years) recruited from the French–Cana...
Published on Dec 20, 2013in PLOS ONE2.78
Melkaye G. Melka5
Estimated H-index: 5
(U of T: University of Toronto),
Michal Abrahamowicz68
Estimated H-index: 68
(McGill University)
+ 6 AuthorsZdenka Pausova41
Estimated H-index: 41
(U of T: University of Toronto)
Visceral fat (VF) promotes the development of metabolic syndrome (MetS), which emerges as early as in adolescence. The clustering of MetS components suggests shared etiologies, but these are largely unknown and may vary between males and females. Here, we investigated the latent structure of pre-clinical MetS in a community-based sample of 286 male and 312 female adolescents, assessing their abdominal adiposity (VF) directly with magnetic resonance imaging. Principal component analysis of the fi...
Published on Nov 11, 2013in PLOS ONE2.78
Katie Goodwin2
Estimated H-index: 2
(U of T: University of Toronto),
Catriona Syme13
Estimated H-index: 13
(U of T: University of Toronto)
+ 7 AuthorsZdenka Pausova41
Estimated H-index: 41
(U of T: University of Toronto)
Objective : Visceral fat (VF) increases cardiometabolic risk more than fat stored subcutaneously. Here, we investigated how well routine clinical measures of adiposity, namely body mass index (BMI) and waist circumference (waist), predict VF and subcutaneous fat (SF) in a large population-based sample of adolescents. As body-fat distribution differs between males and females, we performed these analyses separately in each sex. Design and Methods : VF and SF were measured by magnetic resonance im...
Published on Nov 1, 2013in The Lancet59.10
Harvey Whiteford60
Estimated H-index: 60
(Centre for Mental Health),
Louisa Degenhardt89
Estimated H-index: 89
(University of Melbourne)
+ 10 AuthorsNicole Johns16
Estimated H-index: 16
(UW: University of Washington)
Summary Background We used data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010) to estimate the burden of disease attributable to mental and substance use disorders in terms of disability-adjusted life years (DALYs), years of life lost to premature mortality (YLLs), and years lived with disability (YLDs). Methods For each of the 20 mental and substance use disorders included in GBD 2010, we systematically reviewed epidemiological data and used a Bayesian meta...
Emily B. Falk23
Estimated H-index: 23
(UPenn: University of Pennsylvania),
Luke W. Hyde26
Estimated H-index: 26
(UM: University of Michigan)
+ 16 AuthorsJulie Maslowsky14
Estimated H-index: 14
(UW: University of Wisconsin-Madison)
The last decades of neuroscience research have produced immense progress in the methods available to understand brain structure and function. Social, cognitive, clinical, affective, economic, communication, and developmental neurosciences have begun to map the relationships between neuro-psychological processes and behavioral outcomes, yielding a new understanding of human behavior and promising interventions. However, a limitation of this fast moving research is that most findings are based on ...
Published on Oct 1, 2013in NeuroImage5.81
Klára Marečková5
Estimated H-index: 5
(University of Nottingham),
M. Mallar Chakravarty42
Estimated H-index: 42
+ 8 AuthorsZdenka Pausova41
Estimated H-index: 41
(UdeM: Université de Montréal)
Abstract In our previous work, we described facial features associated with a successful recognition of the sex of the face ( Mareckova et al., 2011 ). These features were based on landmarks placed on the surface of faces reconstructed from magnetic resonance (MR) images; their position was therefore influenced by both soft tissue (fat and muscle) and bone structure of the skull. Here, we ask whether bone structure has dissociable influences on observers' identification of the sex of the face. T...
Published on Oct 1, 2013in International Journal of Obesity4.51
Deborah H. Schwartz6
Estimated H-index: 6
,
LeonardGabriel34
Estimated H-index: 34
+ 5 AuthorsTomáš Paus82
Estimated H-index: 82
Background Obesity, a major risk factor for cardiometabolic disease, is associated with lower cognitive performance from childhood to senescence, especially on tasks of executive function. In the cardiovascular domain, fat stored viscerally rather than elsewhere in the body carries particularly high risk. It is unknown whether this is also true in case of obesity-cognition relationships. The aim of this study is to assess the cross-sectional relationship between visceral fat (VF) and cognitive p...
Published on Sep 1, 2013in JAMA Psychiatry15.92
Darya Gaysina12
Estimated H-index: 12
(University of Leicester),
David M. Fergusson126
Estimated H-index: 126
(University of Otago)
+ 7 AuthorsGordon Thomas Harold45
Estimated H-index: 45
(University of Leicester)
IMPORTANCE: Several studies report an association between maternal smoking during pregnancy and offspring conduct disorder. However, past research evidences difficulty in disaggregating prenatal environmental influences from genetic and postnatal environmental influences. OBJECTIVE: To examine the relationship between maternal smoking during pregnancy and offspring conduct problems among children reared by genetically related mothers and genetically unrelated mothers. DESIGN, SETTING, AND PARTIC...
Cited By12
Newest
Published on May 1, 2019in Psychiatry and Clinical Neurosciences3.49
Naohiro Okada6
Estimated H-index: 6
(UTokyo: University of Tokyo),
Shuntaro Ando11
Estimated H-index: 11
(UTokyo: University of Tokyo)
+ 33 AuthorsMasaya Morita (UTokyo: University of Tokyo)
Published on Feb 1, 2019in International Journal of Epidemiology7.34
Fernando Pires Hartwig13
Estimated H-index: 13
(Medical Research Council),
Neil M Davies20
Estimated H-index: 20
(UoB: University of Bristol)
+ 24 AuthorsAyesha Sajjad7
Estimated H-index: 7
Background: Accumulating evidence suggests that breastfeeding benefits children's intelligence, possibly due to long-chain polyunsaturated fatty acids (LC-PUFAs) present in breast milk. Under a nutritional adequacy hypothesis, an interaction between breastfeeding and genetic variants associated with endogenous LC-PUFAs synthesis might be expected. However, the literature on this topic is controversial. Methods: We investigated this gene × environment interaction through a collaborative effort. T...
Published on Nov 1, 2018in Journal of Human Hypertension1.94
Nizal Sarrafzadegan7
Estimated H-index: 7
(IUMS: Isfahan University of Medical Sciences),
Razieh Hassannejad6
Estimated H-index: 6
(IUMS: Isfahan University of Medical Sciences)
+ 4 AuthorsMarjan Mansourian12
Estimated H-index: 12
(IUMS: Isfahan University of Medical Sciences)
A 10-year longitudinal population-based study entitled Isfahan Cohort Study (ICS) was conducted in 2001–2011 with cardiovascular disease (CVD) as the primary outcome. We considered ICS as a master plan for a multi-level non-communicable disease (NCD) study named Isfahan Cohort Study 2 (ICS2). ICS2 is a multi-generation 10-year cohort study with new goals and outcomes that have been started in 2013, recruiting a sub-sample of ICS (n = 1487) and a new recruited sample (n = 1355) aged 35 years and ...
Published on Sep 1, 2018in Cerebral Cortex5.44
Jean Shin6
Estimated H-index: 6
(U of T: University of Toronto),
Leon French14
Estimated H-index: 14
(U of T: University of Toronto)
+ 7 AuthorsTomáš Paus82
Estimated H-index: 82
Published on Jan 1, 2018in European Journal of Epidemiology6.53
Tonya White44
Estimated H-index: 44
(EUR: Erasmus University Rotterdam),
Ryan L. Muetzel21
Estimated H-index: 21
(EUR: Erasmus University Rotterdam)
+ 10 AuthorsRosa Mulder2
Estimated H-index: 2
(EUR: Erasmus University Rotterdam)
Paediatric population neuroimaging is an emerging field that falls at the intersection between developmental neuroscience and epidemiology. A key feature of population neuroimaging studies involves large-scale recruitment that is representative of the general population. One successful approach for population neuroimaging is to embed neuroimaging studies within large epidemiological cohorts. The Generation R Study is a large, prospective population-based birth-cohort in which nearly 10,000 pregn...
Published on Dec 1, 2017in Scientific Reports4.01
Nadine Parker1
Estimated H-index: 1
(U of T: University of Toronto),
Angelita Pui-Yee Wong3
Estimated H-index: 3
(U of T: University of Toronto)
+ 6 AuthorsTomáš Paus82
Estimated H-index: 82
Income inequality is associated with poor health and social outcomes. Negative social comparisons and competition may involve the hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes in underlying some of these complex inter-relationships. Here we investigate brain maturation, indexed by age-related decreases in cortical thickness, in adolescents living in neighborhoods with differing levels of income inequality and household income. We examine whether inter-regiona...
Published on Jan 2, 2017in Journal of Neuroscience Research4.14
Tomáš Paus82
Estimated H-index: 82
(MIND Institute),
Angelita Pui-Yee Wong3
Estimated H-index: 3
(U of T: University of Toronto)
+ 1 AuthorsZdenka Pausova41
Estimated H-index: 41
(U of T: University of Toronto)
This Mini-Review describes sex differences in 66 quantitative characteristics of the brain and body measured in a community-based sample of 1,024 adolescents 12–18 years of age, members of the Saguenay Youth Study. Using an extensive phenotyping protocol, we have obtained measures in a number of domains, including brain structure, cognition, mental health, substance use, body composition, metabolism, cardiovascular reactivity, and life style. For each measure, we provide estimates of effect size...
Published on Oct 15, 2015in Human Molecular Genetics4.54
Jean Shin6
Estimated H-index: 6
(U of T: University of Toronto),
Celine Bourdon6
Estimated H-index: 6
(U of T: University of Toronto)
+ 14 AuthorsAlexander Leemans46
Estimated H-index: 46
(UU: Utrecht University)
DNA methylation may contribute to the etiology of complex genetic disorders through its impact on genome integrity and gene expression; it is modulated by DNA-sequence variants, named methylation quantitative trait loci (meQTLs). Most meQTLs influence methylation of a few CpG dinucleotides within short genomic regions (<3 kb). Here, we identified a layered genetic control of DNA methylation at numerous CpGs across a long 300 kb genomic region. This control involved a single long-range meQTL and ...
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