trans-Cyclohexanediamines Prevent Thermal Inactivation of Protein: Role of Hydrophobic and Electrostatic Interactions
Abstract
Although solution additives prevent protein misfolding, the mechanism remains elusive. In this paper, we compare the preventive effects of trans-1,2-cyclohexanediamine (1,2-CHDA) and trans-1,4-cyclohexanediamine (1,4-CHDA) on the heat-induced inactivation of ribonuclease A (RNase A) and lysozyme. These additives are more effective in preventing thermal inactivation of the proteins than guanidine (Gdn) and arginine (Arg). The results suggest two...
Paper Details
Title
trans-Cyclohexanediamines Prevent Thermal Inactivation of Protein: Role of Hydrophobic and Electrostatic Interactions
Published Date
Feb 26, 2008
Journal
Volume
27
Issue
4
Pages
253 - 257
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