Methylation of Dietary Flavones Increases Their Metabolic Stability and Chemopreventive Effects

Volume: 10, Issue: 11, Pages: 5002 - 5019
Published: Nov 18, 2009
Abstract
Dietary flavones have promising chemoprotective properties, in particular with regard to cancer, but problems with low oral bioavailability and sometimes unacceptable toxicity have made their use as protective additives to normal diets questionable. However, methylation of free phenolic hydroxyl groups leads to derivatives not susceptible to glucuronic acid or sulfate conjugation, resulting in increased metabolic stability. Methylation also...
Paper Details
Title
Methylation of Dietary Flavones Increases Their Metabolic Stability and Chemopreventive Effects
Published Date
Nov 18, 2009
Volume
10
Issue
11
Pages
5002 - 5019
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