Original paper
The ErbB4 Ligand Neuregulin-4 Protects against Experimental Necrotizing Enterocolitis
Abstract
Necrotizing enterocolitis (NEC) affects up to 10% of premature infants, has a mortality of 30%, and can leave surviving patients with significant morbidity. Neuregulin-4 (NRG4) is an ErbB4-specific ligand that promotes epithelial cell survival. Thus, this pathway could be protective in diseases such as NEC, in which epithelial cell death is a major pathologic feature. We sought to determine whether NRG4-ErbB4 signaling is protective in...
Paper Details
Title
The ErbB4 Ligand Neuregulin-4 Protects against Experimental Necrotizing Enterocolitis
Published Date
Oct 1, 2014
Volume
184
Issue
10
Pages
2768 - 2778
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History