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α-Glucosidase inhibitors isolated from medicinal plants

Published on Sep 1, 2014in Food Science and Human Wellness
· DOI :10.1016/j.fshw.2014.11.003
Zhenhua Yin3
Estimated H-index: 3
(Huanghe Science and Technology College),
Wei Zhang3
Estimated H-index: 3
(Huanghe Science and Technology College)
+ 2 AuthorsWenyi Kang10
Estimated H-index: 10
(Huanghe Science and Technology College)
Abstract
Abstract Objective α -Glucosidase inhibitors can be used as a new class of antidiabetic drug. By competitively inhibiting glycosidase activity, these inhibitors help to prevent the fast breakdown of sugars and thereby control the blood sugar level. This study provides a wealth of information about α -glucosidase inhibitors isolated from medicinal plants; this knowledge will be useful in finding more potent antidiabetic candidates from the natural resources for the clinical development of antidiabetic therapeutics. Results 411 compounds exhibiting α -glucosidase inhibitory activity were summarized and isolated them from medicinal plants. The compound classes isolated include: terpenes (61) from 14 genus, alkaloids (37) from 11 genus, quinines (49) from 4 genus, flavonoids (103) from 24 genus, phenols (37) from 9 genus, phenylpropanoids (73) from 20 genus, sterides (8) from 5 genus, and other types of compounds (43). Conclusion Compounds with α -glucosidase inhibitory activity are abundant in nature and can be obtained from several sources. They have high α -glucosidase inhibitory potential, and can be clinically developed for treating diabetes mellitus.
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