Abstract 5180: Activation of NF- KB by Notch4/Int3 is Rbpj-independant.
Abstract
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC
Transgenic mice expressing the Notch 4 intracellular domain (ICD) (Int3) in the mammary gland have two phenotypes exhibited with 100% penetrance: arrest of mammary alveolar/lobular development and mammary tumorigenesis. Notch4 signaling is mediated primarily through the interaction of Int3 with the transcription repressor/activator Rbpj. Interestingly, Rbpj knockout...
Paper Details
Title
Abstract 5180: Activation of NF- KB by Notch4/Int3 is Rbpj-independant.
Published Date
Apr 15, 2013
Journal
Volume
73
Pages
5180 - 5180
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