Reduced fluidity of dipalmitoyl phosphatidic acid membranes by salicylic acid
Abstract
This paper presents DSC and NMR study of how the kerotolytic drug, salicylic acid (SA), affects the thermotropic and morphological behavior of a model membrane, dipalmitoyl phosphatidic acid (DPPA). The membrane–drug system has been studied in the multilamellar vesicular (MLV) and in the unilamellar vesicular (ULV) forms, for SA/DPPA molar ratios from 0 to 0.5. The mode of interaction of SA molecules with DPPA is similar in MLV and ULV....
Paper Details
Title
Reduced fluidity of dipalmitoyl phosphatidic acid membranes by salicylic acid
Published Date
Jul 1, 2005
Journal
Volume
432
Issue
1
Pages
41 - 46
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