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A review of economic evaluations of genetic testing services and interventions (2004–2009)

Published on Feb 1, 2011in Genetics in Medicine8.68
· DOI :10.1097/GIM.0b013e3182003294
S. Djalalov4
Estimated H-index: 4
(Cancer Care Ontario),
Zahra Musa2
Estimated H-index: 2
(Cancer Care Ontario)
+ 2 AuthorsJeffrey S. Hoch31
Estimated H-index: 31
(Cancer Care Ontario)
Abstract
To review economic evaluations of genetic interventions published between 2004 and 2009 and assess the quality of the identified studies, we searched for economic evaluations of genetic testing and interventions published between 2004 and 2009. Studies that met inclusion criteria were reviewed and their quality then assessed using a validated instrument—the Quality of Health Economic Studies. Of 54 articles identified, 26 met study criteria and were included in the review. These studies span a number of clinical indications, genetic tests, and interventions, but the majority (92%) focuses on genetic interventions for preventive screening and increasing treatment efficacy. The mean quality score for the reviewed studies was 89.8. Comparison of the quality of different study types revealed that cost-utility studies and studies that used a combined decision tree and Markov model had the highest mean quality scores. Clear statements regarding bias, funding source, and study perspective were commonly lacking in the reviewed studies. Although the reviewed studies were of fairly high quality, we found Quality of Health Economic Studies methodology for grading the quality of economic evaluations challenging and observed no statistically significant improvement in quality of studies between the periods of 1995–2004 and 2004–2009.
  • References (39)
  • Citations (22)
References39
Newest
#1Jennifer E. Mersereau (UCSF: University of California, San Francisco)H-Index: 17
#2Beth A. Plunkett (NU: Northwestern University)H-Index: 11
Last.Marcelle I. Cedars (UCSF: University of California, San Francisco)H-Index: 44
view all 3 authors...
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#2J. Bryant (UCL: University College London)H-Index: 1
Last.Christine Patch (UCL: University College London)H-Index: 16
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#1Stefan Vegter (UG: University of Groningen)H-Index: 18
#2Cornelis Boersma (UG: University of Groningen)H-Index: 15
Last.Maarten Postma (UG: University of Groningen)H-Index: 44
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#1Maartje Nielsen (LUMC: Leiden University Medical Center)H-Index: 24
#2Frederik J. Hes (LUMC: Leiden University Medical Center)H-Index: 22
Last.Wilbert B. van den Hout (LUMC: Leiden University Medical Center)H-Index: 30
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Cited By22
Newest
#1S. Djalalov (Westminster International University in Tashkent)H-Index: 4
Last.Jeffrey S. Hoch (UC Davis: University of California, Davis)H-Index: 31
view all 5 authors...
#1Sarah Wordsworth (University of Oxford)H-Index: 20
#2James Buchanan (University of Oxford)H-Index: 38
Last.Adrian TowseH-Index: 1
view all 3 authors...
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