Molecular changes in brain aging and Alzheimer's disease are mirrored in experimentally silenced cortical neuron networks
Abstract
Activity-dependent modulation of neuronal gene expression promotes neuronal survival and plasticity, and neuronal network activity is perturbed in aging and Alzheimer's disease (AD). Here we show that cerebral cortical neurons respond to chronic suppression of excitability by downregulating the expression of genes and their encoded proteins involved in inhibitory transmission (GABAergic and somatostatin) and Ca2+ signaling; alterations in...
Paper Details
Title
Molecular changes in brain aging and Alzheimer's disease are mirrored in experimentally silenced cortical neuron networks
Published Date
Jan 1, 2012
Journal
Volume
33
Issue
1
Pages
205.e1 - 205.e18
Citation AnalysisPro
You’ll need to upgrade your plan to Pro
Looking to understand the true influence of a researcher’s work across journals & affiliations?
- Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
- Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.
Notes
History