Polymerase Dynamics at the Eukaryotic DNA Replication Fork

This review discusses recent insights in the roles of DNA polymerases (Pol) δ and ∊ in eukaryotic DNA replication. A growing body of evidence specifies Pol ∊ as the leading strand DNA polymerase and Pol δ as the lagging strand polymerase during undisturbed DNA replication. New evidence supporting this model comes from the use of polymerase mutants that show an asymmetric mutator phenotype for certain mispairs, allowing an unambiguous strand...