Reduction in alkaline phosphatase is associated with longer survival in primary sclerosing cholangitis, independent of dominant stenosis

Summary Background Alkaline phosphatase ( ALP ) is an important serum marker in primary sclerosing cholangitis ( PSC ). Patients with obstruction of the large bile ducts due to dominant strictures ( DS ) are a special, clinically important phenotype. Aim To determine the impact of ALP reduction on liver transplantation‐free survival in PSC patients with DS . Methods Prospective cohort study in 215 PSC patients. We performed subgroup analysis for...