Ubiquitin is phosphorylated by PINK1 to activate parkin

Nature64.80
Volume: 510, Issue: 7503, Pages: 162 - 166
Published: Apr 30, 2014
Abstract
Ubiquitin, known for its role in post-translational modification of other proteins, undergoes post-translational modification itself; after a decrease in mitochondrial membrane potential, the kinase enzyme PINK1 phosphorylates ubiquitin at Ser 65, and the phosphorylated ubiquitin then interacts with ubiquitin ligase (E3) enzyme parkin, which is also phosphorylated by PINK1, and this process is sufficient for full activation of parkin enzymatic...
Paper Details
Title
Ubiquitin is phosphorylated by PINK1 to activate parkin
Published Date
Apr 30, 2014
Journal
Volume
510
Issue
7503
Pages
162 - 166
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