Tunicamycin suppresses cisplatin-induced HepG2 cell apoptosis via enhancing p53 protein nuclear export

Cisplatin is a widely used anticancer drug; however, resistance to cisplatin-based chemotherapy is a major cause of treatment failure in patients with tumors. The present study was undertaken to investigate whether and how endoplasmic reticulum (ER) stress initiated by tunicamycin, which inhibits glycosylation, influences cisplatin-induced apoptosis in HepG2 cells. Pretreatment of HepG2 cells with ER stress inducers brought about a decrease in...