Polyclonal Antibody Effects on the Human Cardiac 5-HT4(e) Receptors Depend Upon the Expression System
Abstract
The initial objective of this work was to examine the effects of an antibody (Anti-G21V) directed against the second extracellular loop of human heart 5-HT4 receptors expressed in Chinese hamster ovary (CHO) cells. The antibody anti-G21V had no effect upon either basal cAMP– or 5-HT–evoked increases in cAMP in CHO cells, whereas it had shown an agonist-like effect in COS-7 cells. Analysis of agonist fractions of h5-HT4(e) receptors in CHO and...
Paper Details
Title
Polyclonal Antibody Effects on the Human Cardiac 5-HT4(e) Receptors Depend Upon the Expression System
Published Date
May 1, 2004
Journal
Volume
10
Issue
3-4
Pages
125 - 129
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Notes
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