Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB
Abstract
The abilities of NF-κB to promote cell proliferation, suppress apoptosis, promote cell migration, and suppress differentiation apparently have been co-opted by cellular and viral oncoproteins to promote oncogenesis (Figure (Figure2).2). Direct evidence, using both in vitro and in vivo models, indicates that NF-κB is required for oncogenesis, probably at multiple levels. NF-κB likely plays an important role in the early events of oncogenesis,...
Paper Details
Title
Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB
Published Date
Feb 1, 2001
Volume
107
Issue
3
Pages
241 - 246
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