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Body fat and circulating leukocytes in children

Published on Jun 1, 2006in International Journal of Obesity4.51
· DOI :10.1038/sj.ijo.0803227
Frank Zaldivar29
Estimated H-index: 29
(UCI: University of California, Irvine),
Robert G. McMurray45
Estimated H-index: 45
(UNC: University of North Carolina at Chapel Hill)
+ 3 AuthorsDan M. Cooper48
Estimated H-index: 48
(UCI: University of California, Irvine)
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Abstract
Top of pageAbstract Objective:  To determine the effects of obesity on baseline levels of circulating granulocytes, monocytes, and lymphocyte subtypes in otherwise healthy children. Design:  Two group comparison of leukocytes in normal weight control and overweight children. Subjects:  In total, 38 boys and girls, ages 6–18 years, divided in two groups: normal weight, (NW, BMI 85th %tile, n=23). Measurements:  BMI obtained from direct measures of height and body mass. Body fat was assessed by DEXA. Complete blood counts (CBC) were obtained by standard clinical hematology methods and surface antigen staining by flow cytometry. Results:  The OW group compared to the NW group had increased total leukocytes counts (P=0.011), neutrophils (P=0.006), monocytes (P=0.008), total T (CD3) lymphocytes (P=0.022), and Helper T (CD4+) cells (P=0.003). Significant correlations were evident between leukocytes, and BMI percentile, BMI, or percent body fat. Neither lean body mass nor VO2peak per unit lean body mass were significantly related to any of the leukocytes. Percent body fat and BMI percentile were positively correlated (P<0.05) to total T cells (CD3) and/or helper T cells (CD4+). Conclusion:  A group of 23 overweight children displayed elevated counts in most types of circulating immune cells, suggesting the presence of low-grade systemic inflammation, a known pathogenetic mechanism underlying most long-term complications of obesity. Our data provide an additional rationale for the importance of avoiding or correcting pediatric obesity. Keywords: neutrophils, monocytes, granulocytes, lymphocytes, natural killer cells
  • References (33)
  • Citations (82)
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References33
Newest
#1Naval K. Vikram (AIIMS: All India Institute of Medical Sciences)H-Index: 25
#2Anoop Misra (AIIMS: All India Institute of Medical Sciences)H-Index: 51
Last.Talwar Kk (AIIMS: All India Institute of Medical Sciences)H-Index: 3
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#1Timothy P. Scheett (UConn: University of Connecticut)H-Index: 18
#2Dan Nemet (UCI: University of California, Irvine)H-Index: 12
Last.Dan M. Cooper (UCI: University of California, Irvine)H-Index: 48
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Cited By82
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#1Junjun Jiang (Guangxi Medical University)H-Index: 6
#2Xionglin Qin (CDC: Centers for Disease Control and Prevention)
Last.Fengxiang Qin (Guangxi Medical University)H-Index: 2
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#1Anne E. Dixon (UVM: University of Vermont)H-Index: 24
#2Ubong Peters (UVM: University of Vermont)H-Index: 3
#1Kijin Kim (KMU: Keimyung University)H-Index: 9
#2Nayoung Ahn (KMU: Keimyung University)H-Index: 6
Last.Yongjin Jung (KMU: Keimyung University)
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#1Young Bok Lee (Catholic University of Korea)H-Index: 9
#2J. Hyun Lee (Catholic University of Korea)H-Index: 8
Last.Yong Gyu Park (Catholic University of Korea)H-Index: 24
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#1Gyeong Im Yu (KMU: Keimyung University)H-Index: 4
#2Sang Eun Jun (KMU: Keimyung University)H-Index: 1
Last.Dong Hoon Shin (KMU: Keimyung University)H-Index: 17
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#1Abdenour Bounihi (USTHB: University of Science and Technology Houari Boumediene)H-Index: 2
#2Arezki Bitam (USTHB: University of Science and Technology Houari Boumediene)H-Index: 3
Last.Elhadj-Ahmed Koceir (USTHB: University of Science and Technology Houari Boumediene)H-Index: 5
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