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Body fat and circulating leukocytes in children

Published on Jun 1, 2006in International Journal of Obesity4.514
· DOI :10.1038/sj.ijo.0803227
Frank Zaldivar28
Estimated H-index: 28
(UCI: University of California, Irvine),
Robert G. McMurray46
Estimated H-index: 46
(UNC: University of North Carolina at Chapel Hill)
+ 3 AuthorsDan M. Cooper47
Estimated H-index: 47
(UCI: University of California, Irvine)
Abstract
To determine the effects of obesity on baseline levels of circulating granulocytes, monocytes, and lymphocyte subtypes in otherwise healthy children. Two group comparison of leukocytes in normal weight control and overweight children. In total, 38 boys and girls, ages 6–18 years, divided in two groups: normal weight, (NW, BMI 85th %tile, n=23). BMI obtained from direct measures of height and body mass. Body fat was assessed by DEXA. Complete blood counts (CBC) were obtained by standard clinical hematology methods and surface antigen staining by flow cytometry. The OW group compared to the NW group had increased total leukocytes counts (P=0.011), neutrophils (P=0.006), monocytes (P=0.008), total T (CD3) lymphocytes (P=0.022), and Helper T (CD4+) cells (P=0.003). Significant correlations were evident between leukocytes, and BMI percentile, BMI, or percent body fat. Neither lean body mass nor VO2peak per unit lean body mass were significantly related to any of the leukocytes. Percent body fat and BMI percentile were positively correlated (P<0.05) to total T cells (CD3) and/or helper T cells (CD4+). A group of 23 overweight children displayed elevated counts in most types of circulating immune cells, suggesting the presence of low-grade systemic inflammation, a known pathogenetic mechanism underlying most long-term complications of obesity. Our data provide an additional rationale for the importance of avoiding or correcting pediatric obesity.
  • References (33)
  • Citations (84)
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References33
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#1Stephen E. Borst (UF: University of Florida)H-Index: 27
Insulin resistance is an important component of the metabolic syndrome associated with obesity. Early-stage insulin-resistance and related mild glucose intolerance may be compensated by increased insulin secretion. When combined with impaired insulin secretion, insulin resistance plays an important role in type 2 diabetes (1). Insulin-resistance is also associated with a variety of pathological conditions, including trauma, infection, and cancer. Obesity and type 2 diabetes are the most common m...
217 CitationsSource
#1William T. Shearer (BCM: Baylor College of Medicine)H-Index: 49
#2Howard M. Rosenblatt (BCM: Baylor College of Medicine)H-Index: 32
Last. Stephen A. Spector (UCSD: University of California, San Diego)H-Index: 81
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Abstract Background Peripheral blood lymphocyte subsets need to be determined in a large, urban, minority-predominant cohort of healthy children to serve as suitable control subjects for the interpretation of the appearance of these cells in several disease conditions, notably pediatric HIV-1 infection. Objective We sought to determine the distribution of lymphocyte subsets in healthy urban-dwelling infants, children, and adolescents in the United States. Methods Lymphocyte subsets were determin...
534 CitationsSource
#1Naval K. Vikram (AIIMS: All India Institute of Medical Sciences)H-Index: 25
#2Anoop Misra (AIIMS: All India Institute of Medical Sciences)H-Index: 47
Last. Randeep Guleria (AIIMS: All India Institute of Medical Sciences)H-Index: 28
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Abstract Objective: To investigate the relationships of sub-clinical inflammation and regional and generalized obesity and lipids in adolescent and young adult Asian Indians in north India. Methods: We determined serum levels of C-reactive protein (CRP), a marker for sub-clinical inflammation, body mass index (BMI), waist circumference (WC), waist-to-hip ratio (W-HR), four skinfolds (biceps, triceps, subscapular and suprailiac), percentage of body fat (% BF) and lipid profile in 377 healthy adol...
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#1Dan Nemet (UCI: University of California, Irvine)H-Index: 14
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Recent evidence suggests a role for adipose derived cytokines (adipocytokines) such as tumor necrosis factor-α (TNF-α), IL-6, and the recently discovered adiponectin in the mechanism of impaired glucose regulation and atherosclerosis in adults. However, the relationship between adipocytokines and body composition, fasting insulin, and fitness is virtually unknown children. Fasting blood sampling was performed in 30 healthy, predominately Hispanic- and Asian-American children (16 boys, mean age 1...
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Background: Physical activity has been associated with a reduced risk of coronary heart disease, but the mechanism underlying this association is unclear. Because coronary heart disease is increasingly seen as an inflammatory process, it might be reasonable to hypothesize that physical activity reduces risk of coronary heart disease by reducing or preventing inflammation. Methods: The study examined the relationship between physical activity and elevated inflammation as indicated by a high C-rea...
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TNFα expression of subcutaneous adipose tissue in obese and morbid obese females: relationship to adipocyte LPL activity and leptin synthesis
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Abstract Several studies have shown that humoral markers of inflammation and endothelial dysfunction are predictive of macrovascular events, and correlated with indirect measures of adiposity and insulin action, thus providing a possible link between obesity, insulin resistance and atherosclerosis. We examined the relationship between humoral markers of inflammation and endothelial dysfunction and direct measures of adiposity and insulin action in Pima Indians, a population with a very high prev...
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