Symptoms and signs of the initial prodrome of bipolar disorderA systematic review

Systematic studies addressing symptoms, signs and temporal aspects of initial bipolar prodrome are reviewed to identify potential clinical targets for early intervention. The databases PsycINFO, PubMed, EMBASE and British Nursing Index were searched for original studies. Eight studies were identified. Irritability and aggressiveness, sleep disturbances, depression and mania symptoms/signs, hyperactivity, anxiety, and mood swings are clusters...