Mechanisms of Neuronal Degeneration in Alzheimer's Disease

Alzheimer's disease (AD) is the most common cause of progressive cognitive decline in the aged population. The triad of amyloid plaques, neurofibrillary tangles, and dementia that characterize AD was first described by Alois Alzheimer in 1907. Despite considerable progress in elucidating the molecular components of the brain lesions, the mechanism of neuronal degeneration in AD has been unclear. However, recent advances in molecular genetics...