Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling
Abstract
High-fat diet (HFD) and inflammation are key contributors to insulin resistance and type 2 diabetes (T2D). Interleukin (IL)-1β plays a role in insulin resistance, yet how IL-1β is induced by the fatty acids in an HFD, and how this alters insulin signaling, is unclear. We show that the saturated fatty acid palmitate, but not unsaturated oleate, induces the activation of the NLRP3-ASC inflammasome, causing caspase-1, IL-1β and IL-18 production....
Paper Details
Title
Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling
Published Date
Apr 10, 2011
Journal
Volume
12
Issue
5
Pages
408 - 415
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