A Framework for the Economic Evaluation of Sequential Therapies for Chronic Conditions

Cost-effectiveness models often require the consideration of a sequence of treatments. This enables the downstream implications of a treatment to be captured, and alternative sequences to be compared. However, when many treatments are available, the number of feasible sequences can be large. Also, if the objective is to maximise net benefit for a given ICER threshold, then a comparative analysis to identify the optimal sequence may not be...